In the evaluation of obesity consider :

Medications Associated with Weight Gain
Psychotropic agents
Antidepresssant drugs (tricyclic antidepressants, monoamine oxidase inhibitors)
Antipsychotic drugs
Lithium
Anticonvulsant agents
Valproic acid (Depakene)
Carbamazepine (Tegretol)
Steroid hormones
Corticosteroids
Estrogen, progesterone, testosterone or other anabolic/androgenic steroids
Insulin and most oral hypoglycemic agents

Dickerson LM, Carek PJ
Drug Therapy for Obesity
Am Fam Physician 2000;61;2131-8,2143

In the management of obesity the comorbidity may ahev to be addressed :

Type 2 diabetes mellitus*
Hypertension
Dyslipidemia
Macrovascular disease
Cancer (endometrial, ovarian, breast, gallbladder, prostate, colon)
Menstrual irregularities, decreased fertility, hirsutism
Gallbladder disease
Restrictive lung disease, sleep apnea
Osteoarthritis
Gout
Thromboembolic disease

Dickerson LM, Carek PJ
Drug Therapy for Obesity
Am Fam Physician 2000;61;2131-8,2143

Comparative efficacy of pharmacologic management of obesity :

Phenylpropanolamine (Dexatrim)
20 - 75 mg for 14 weeks 6 kg mean weight loss

Phentermine (Ionamin)
30.0 - 37.5 mg for 24 weeks 10 kg mean weight loss

Fluoxetine (Prozac)
60 mg for 12 weeks 6 kg mean weight loss
60 mg for 52 week 2 kg mean weight loss

Sibutramine (Meridia)
10 - 15 mg daily for 24 weeks 6 kg mean weight loss
15 - 30 mg daily for 36 weeks 2.6 kg mean weight loss

Orlistat (Xenical)
120 mg tid for 52 weeks 3 kg mean weight loss

Dickerson LM, Carek PJ
Drug Therapy for Obesity
Am Fam Physician 2000;61;2131-8,2143