1)      Unexplained obstructed voiding syndrome in a female with abdominal and/or VE mass (exclude ovarian Ca if not due to fibroids, GIT, or GUS masses)

2)      Unexplained obstructed voiding syndrome in a male DRE and PSA indicated to exclude prostate Ca

3)      LUTS and rising age-specific PSA levels (even if DRE is normal)