1)      Severe motor retardation

2)      More sleep more appetite and weight gain

3)      Sensitivity to rejection

4)      Earlier onset of depression in adolescence

5)      More frequent depressive episodes

6)      Behavioral activation and mood lability during antidepressant therapy

7)      Periods of increased energy and activity with less need for sleep

8)      Cormorbid anxiety disorders, substance use disorders, and attention deficit disorders

9)      Lack of response to antidepressant treatment

10)    F/H of bipolar disorder in a first-degree biological relative

11)    F/H any affective disorder in multiple generations

12)    Recurrent interpersonal conflicts

13)    Extreme extroversion

14)    Episodic impulsivity – legal problems related to sexual promiscuity, STD, sudden frequent job changes