1)      Pain, swelling, tenderness, warmth, and redness in 1 leg particularly in the presence of the following risk factors – prolonged sitting, bed rest, immobilization, recent surgery on hip, knee, or gyne surgery, trauma particularly fractures, childbirth within the last 6/12, used if OC’s (Deep vein thrombosis, See Well’s (N) Clinical prediction rule for DVT)

2)      Compartment syndrome – pain out of proportion to the injury, severe limb pain following an injury particularly high energy and high-velocity trauma, long bone fractures, penetrating injuries, vascular injuries, crush injuries, on anticoagulation, severe pain out of proportion to the injury, burning sensation and tightness, limb paresthesias, pain with passive stretching of muscle earliest indicators,  direct pressure over the compartment tender, sensory loss, and motor paralysis.  Early diagnosis and timely referral are the mainstay of good management.  Traditional 5P’s of pain, paresthesia, poikilothermia, pulselessness, and pallor are unreliable, and late developments as in compartment syndrome diagnosis should be established within 6 hrs.

3)      Erysipelas in infants, elderly, and in the immunocompromised – severe infections requiring IV antibiotics