1)      Failure to thrive – deceleration of linear growth

2)      Weight loss unintentional

3)      Patient age less than 4 years

4)      Nocturnal pain

5)      F/H Inflammatory Bowel Disease

6)      F/H Peptic ulcer disease

7)      Arthritis/arthralgia

8)      Aphthous ulcers/stomatitis

9)      Rashes, diarrhea, vomiting, fever, rectal bleeding

10)  Hemetemesis, bile-stained vomitus, GIT blood loss,

11)  Clubbing

12)  Hepatosplenomegaly

13)  Perianal disease

14)  Fecal occult blood, anemia, high ESR, hypoalbuminemia, high aminotransferases, dysuria, Hematuria, pyuria, eosinophilia, steatorrhea

15)  Pain away from the umbilicus

16)  Unexplained fever

17)  Changes in bowel function

18)  Intermittent fecal incontinence

19)  Right lower abdominal mass consistent with colonic origin (Urgent referral for colonoscopy)

20)  Obesity, hypertriglyceridemia

21)  Abdominal pain colicky in 3/12-6 yrs, episodes of inconsolable crying, stools red currant jelly, abdominal mass in the epigastrium or right upper quadrant, vomiting, bile stained vomitus, blood and mucus stools (Intussusception)

22)  Significant vomiting

23)  Severe chronic diarrhea

24)  Persistent right upper or lower quadrant pain

25)  Scrotal or testicular pain

26)  Recurrent cyclical monthly abdominal pain in females around puberty (imperforate hymen)