The intervention group had 0.05 percent topical tretinoin applied for 10 minutes per day, followed by a saline rinse, for a total of four weeks. All wounds had cadexomer iodine gel (Iodosorb) applied between treatments with tretinoin or placebo ointment.
Tom WL, et al. The effect of short-contact topical tretinoin therapy for foot ulcers in patients with diabetes. Arch Dermatol. November 2005;141:1373–7.